Abstract: New buildings are being constructed and existing buildings retrofitted to be more energy efficient to meet increasingly stringent Department of Defense (DoD) energy standards. Although these standards save energy and lower operational costs, they also limit fresh air within a structure and can cause a buildup of harmful substances in indoor environments. Of particular concern are molds, which can put building occupants at risk and damage infrastructure. One possible solution to this increasing Army problem is to coat building materials with photocatalytic paints, which have the ability to both destroy microorganisms as well as the toxic byproducts they produce. This work compared two next-generation photocatalytic coatings against three more traditional antimicrobial-infused coatings for their ability to resist fungal contamination using three accelerated test conditions. Under each test condition the photocatalytic coatings were found to perform poorly compared to the antimicrobial-infused coatings. Moreover, the control coating, which contained no active antimicrobial (standard latex paint), performed as well as or better than all the antimicrobial coatings tested. This suggested that there may be little benefit to using antimicrobial coatings to inhibit fungal colonization over a standard latex paint; however, further testing is required to confirm this perception.