Abstract: A series of 10 water-exchange studies were conducted from 2019 to 2021 at two sites, Clover Island and Osprey Point, within the McNary Pool of the Columbia River on the Oregon-Washington border. Six of the studies incorporated a barrier curtain or bubble curtain, whereas the other four studies did not include any device to mitigate water exchange. Once annually, diquat aquatic herbicide was applied concurrently with rhodamine water tracing (RWT) dye at the Osprey Point site (2019–2021) to control flowering rush. An additional plot, Clover Island Reference, served as the nontreated control to the Osprey Point treatment plot. Pre- and posttreatment vegetation surveys were conducted in 2019, 2020, and 2021 to determine flowering rush control, treatment impacts to water quality, and nontarget species response. This study sought to (1) document the use of barrier curtains and bubble curtains as potential methods for reducing water exchange and increasing herbicide concentration exposure times within potential flowering rush treatment areas, (2) evaluate bulk water exchange and selective control of flowering rush under varying reservoir operations, and (3) use the results from these studies to provide guidance for managing submersed flowering rush infestations on the McNary Pool, Columbia River, and similar run-of-the-river impoundments.