Abstract: Microseira wollei (formerly Lyngbya wollei) has grown to noxious densities within Lake St. Clair, located between Lake Erie and Lake Huron. De-spite the limited data on this cyanobacterium within Lake St. Clair, data exists for M. wollei within the Great Lakes region and in the southeastern United States, where water resource managers have been managing growths for decades. These data provide pertinent insights into the environmental distribution, environmental drivers, risks, and management of M. wollei, which is mainly distributed within eastern states and provinces in North America, from Canada to Florida. Environmental drivers may be site-specific and specific to the M. wollei population; therefore, the environmental drivers identified in this literature review are a starting point to inform further investigations. M. wollei within Lake St. Clair may pose risks to humans. Risks may originate from toxins, disinfection by-products, and, potentially, fecal indicator bacteria. M. wollei has the potential to produce a range of toxins; however, the most prevalent toxins are saxitoxins, a group of neurotoxins. This literature review will help the US Army Corps of Engineers Detroit District; Macomb County, Michigan; and other interested parties understand potential triggers for growth, communicate risks, and help develop an adaptive management framework.