Abstract: Infrasound—that is, acoustic waves with frequencies below the threshold of human hearing—has historically been used to detect and locate distant explosive events over global ranges (≥1,000 km). Simulations over these ranges have traditionally relied on large-scale, synoptic meteorological information. However, infrasound propagation over shorter, local ranges (0–100 km) may be affected by smaller, mesoscale meteorological features. To identify the effects of these mesoscale meteorological features on local infrasound propagation, simulations were conducted using the Weather Research and Forecasting (WRF) meteorological model to approximate the meteorological conditions associated with a series of historical, small-scale explosive test events that occurred at the Big Black Test Site in Bovina, Mississippi. These meteorological conditions were then incorporated into a full-wave acoustic model to generate meteorology-informed predictions of infrasound propagation. A series of WRF simulations was conducted with varying degrees of horizontal resolution—1, 3, and 15 km—to investigate the spatial sensitivity of these infrasound predictions. The results illustrate that convective precipitation events demonstrate potentially observable effects on local infrasound propagation due to strong, heterogeneous gradients in temperature and wind associated with the convective events themselves. Therefore, to accurately predict infrasound propagation on local scales, it may be necessary to use convection-permitting meteorological models with a horizontal resolution ≤4 km at locations and times that support mesoscale convective activity.